Thomas King, Ph.D
My research interests concern the genetic analysis of development in mammals. With the goal of gaining access to the molecular biology underlying the development of the mammalian integument, my laboratory is attempting to positionally clone a series of spontaneously-occurring hair variants in mice.
BM Brennan, MT Huynh, MA Rabah, HE Shaw, JJ Bisaillon, LA Radden II, TV Nguyen, & TR King. (2015) The mouse wellhaarig (we) mutations result from defects in epidermal-type transglutaminase 3 (Tgm3). Molecular Genetics and Metabolism Reports (Epub ahead of print)
JJ Bisaillon, LA Radden II, ET Szabo, SR Hughes, AM Feliciano, AV Nesta, B Petrovic, KM Palanza, D Lancinskas, TA Szmurlo, DC Artus, MA Kapper, JP Mulrooney, & TR King. (2014) The retarded hair growth (rhg) mutation in mice is an allele of ornithine aminotransferase (Oat). Molecular Genetics and Metabolism Reports1:378-390.
F Ramirez, AM Feliciano, EB Adkins, KM Child, LA Radden II, A Salas, N Vila-Santana, JM Horak, SR Hughes, DV Spacek, & TR King. (2013) The juvenile alopecia mutation (jal) maps to mouse Chromosome 2, and is an allele of GATA binding protein 3 (Gata3). BMC Genetics14:40.
D.V. Spacek, A.F. Perez, K.M. Ferranti, L.K.-L Wu, D.M. Moy, D.R. Magnan, & T.R. King. (2010) The mouse frizzy (fr) and rat “hairless” (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8). Experimental Dermatology19:527-532.
D.R. Magnan, D.V. Spacek, N. Ye, Y.-C. Lu & T.R. King (2009) The male sterility and histoincompatibility (mshi) mutation in mice is a natural variant of microtubule-associated protein 7 (Mtap7). Molecular Genetics and Metabolism97:155-162.
E.L. Paul, R. Badal, D.S. Thompson, D.R. Magnan, F.M. Soucy, I.M. Khan, R.A. Haughton & T.R. King (2008). The mouse frizzy mutation (fr) maps between D7Csu5 and D7Mit165. Experimental Dermatology17:640-644.
K. Ahearn, G. Akkouris, P.R. Berry, R. R. Chrisslius, I. Crooks, A.K. Dull, S. Grable, J. Jeruzal, J. Lanza, C. Lavoie, R. A. Maloney, M. Pitruzzello, R. Sharma, T.A. Stoklasek, J. Tweeddale & T.R. King. The Charles River “hairless” rat mutation: Maps to Chromosome 1, allelic with fuzzy, and a likely orthologue of mouse frizzy. Journal of Heredity93:210-213.
E.H. Hall, J.A. Lathrop, B. Medina, R.J. Mutcherson II & T.R. King (2000) The hypotrichosis-generating shorn (shn) mutation maps to distal Chromosome 7 in the Norway rat. Journal of Heredity91:345-347.
M. C. Rule, R. J. Mutcherson II, A. D. Foss, T. K.-X. Nguyen, K. A. Myrie & T. R. King (1999) Mouse male sterility and histocompatibility (mshi) maps between the D10Mit51/168/212 cluster and D10Mit213. Mammalian Genome10:447-450.
A. L. Hildebrandt, A. M. Cantwell, M.C. Rule & T.R. King (1999) The H-mshi antigen is conserved between standard BALB/cBy, C57BL/6J, and wild-derived CAST/Ei and SPRET/Ei inbred strains of mice. Immunogenetics49:666-672.
J. P. Turner, J. E. Carpentino, A. M. Cantwell, A. L. Hildebrandt, K. A. Myrie & T. R. King (1997) Molecular genetic mapping of the mouse male sterility and histoincompatibility (mshi) mutation on proximal Chromosome 10.Genomics39, 1-7.