Barry Hoopengardner, Ph.D
The focus of my research is RNA editing, a process by which the coding and stability
of an RNA message can be changed post-transcriptionally. Many targets of this process
are components of nervous signaling. The primary goals of my lab are to examine species
such as neurological model organisms and arthropod pests for novel editing sites and
then to characterize these editing sites in regard to functional significance. Another
goal of my work is to understand the regulation of the timing and tissue-specificity
I am also very interested in the role that editing plays in evolution, and an additional
focus of my research is to examine the involvement of RNA editing in the formation
of social systems in insects.
Rieder, LE, Staber, CJ, Hoopengardner, B, & Reenan, RA (2013). Tertiary structural elements determine the extent and specificity of
messenger RNA editing. Nature Communications. 4:2232
Pozo, P and Hoopengardner, B (2012). Identification and characterization of two novel
RNA editing sites in grin1b transcripts of embryonic Daniorerio. Neural Plasticity.2012:173728
Hoopengardner, B (2006). Adenosine-to-Inosine RNA Editing: Perspectives and Predictions. Mini-Reviews in Medicinal Chemistry. 6:1213-1216
Hoopengardner B, Bhalla T, Stabler C, and Reenan R (2003). Nervous system targets of RNA editing identified by comparative genomics.
Hoopengardner B and Helfland SL (2002). Temperature compensation and temporal expression mediated by an enhancer
element in Drosophila. Mechanisms of Development110:27-37.